Plague is a highly contagious and deadly infectious disease caused by *Yersinia pestis*, characterized by rapid onset, high infectivity, and high mortality, posing a serious threat to human health. On July 5, 2020, Bayannur, Inner Mongolia, confirmed one case of bubonic plague and issued a Level III plague warning on the same day! In recent years, plague has shown a resurgence trend. In 1994, India reported an outbreak of plague with 876 cases and 54 deaths. In August 2017, Madagascar experienced the worst pneumonic plague outbreak in 25 years. In 2019, China reported 5 cases of plague and 1 death. Timely diagnosis is crucial for plague prevention and control.

Nanjing Miaodi Biotechnology Co., Ltd. can provide recombinant F1 protein of *Yersinia pestis* (Fig. 1) and paired monoclonal antibodies against F1 as raw materials for immunodiagnostic reagent companies, for use in the development of immunological reagents such as colloidal gold and ELISA (Fig. 2). We also offer plague antigen detection kits with a sensitivity of up to 5 ng/ml.

Extensive experimental data demonstrate that this recombinant protein exhibits excellent diagnostic specificity and sensitivity, effectively identifying infected human and animal sera. Our company provides truncated Yersinia pestis F1 recombinant protein and paired monoclonal antibodies, both with a purity exceeding 95%, and both dissolved in 0.01M, pH 7.3 PBS.

     FFig. 1. Recombinant expression and purification of truncated recombinant F1 protein from Yersinia pestis.

Fig. 2. Schematic diagram of a double-antibody sandwich ELISA based on F1.

Product Code: Yersinia pestis F1 paired antibody (MAb0197/MAb0199)