Scrub typhus, also known as scrub typhus, is an important zoonotic disease prevalent in Asia and the Pacific. The pathogen causing the disease is *Orientia tsutsugamuchi*, an obligate intracellular parasite, Gram-negative, with several antigen-specific serotypes, including Gilliam, Karp, Kato, and Kawasaki. In my country, scrub typhus is widespread, with wild rodents serving as natural reservoir hosts. Humans are primarily infected through bites from the chigger mite during outdoor activities. Due to the lack of characteristic clinical symptoms (primarily fever, with some patients exhibiting eschar), patients are often misdiagnosed or missed, leading to serious consequences. Our company has developed a human IgM antibody diagnostic kit targeting the 56 kDa antigen of the pathogen, for both early diagnosis of human infection and confirmation of past infections. The total antibody diagnostic kit can also be used for seroepidemiological surveys in humans and animals. Validated on a large number of clinical specimens, the kit has good specificity and sensitivity, and can effectively identify serotypes such as Gilliam, Karp, Kato, and Kawasaki.

A double-antigen sandwich ELISA detection system was constructed using the 56 kDa protein as the diagnostic target. By detecting total scrub typhus-specific antibodies in the serum of infected individuals during the acute and/or convalescent phases, it provides a definitive diagnosis of current or past infection (based on the high specificity of this diagnostic reagent!). In addition, this reagent can also detect total scrub typhus-specific antibodies in the serum of humans and various animals (including livestock and poultry), for use in seroepidemiological surveys.

Product Code: Scrub Typhus Total Antibody Diagnostic Kit (ES41004)